February 13, 2014

Factors responsible for abortion

1. Endocrine and metabolic factors -
Luteal phage defect (LPD) results in early miscarriage as implantation and plancental are not supported adequately. Deficient progesterone secretion from corpus luteum or poor endometrial response to progesterone is the cause. Diabetes mellitus when poorly controlled, causes increased miscarriage.

2. Anatomical abnormalities - 
These are related mostly to the second trimester abortions.
- Cervical incompetance.
- Congenital malformation of the uterus is cause of fetal loss.
- Reduced intrauterine volume.
- Increased uterine irritability and contraction.
- Intrauterine adhesions interfere with implantation, placental and fetal growth.

3. Infections -
Infections are accepted causes of late as well as early abortions. Infections could be :
i) Viral :- Rubella, HIV.
ii) Parasitic :- Toxoplasma, malaria.
iii) Bacterial :- Chlamydia, brucella.


7. Others -
- Maternal medical illness.
- Cyanotic heart disease (CHD).
- Blood group incompatibility.
- Premature rupture of membranes.
- Inherited thrombophilia.

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